Perspectives Perturbation of the normal immune system in patients with CLL
نویسندگان
چکیده
Haematology Oncology Group, Cancer Sciences Unit, Cancer Research UK Centre and National Institute for Health Research Experimental Cancer Medicine Centre, University of Southampton, Faculty of Medicine, Southampton, United Kingdom; Haematology Department, University Hospital Southampton National Health Service Trust, Southampton, United Kingdom; and School of Cancer Sciences, University of Birmingham & University
منابع مشابه
Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia
Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreate...
متن کاملمطالعه تغییرات هورمونی در بیماران مبتلا به لوسمی لنفاوی مزمن (CLL)
Results of some cancer researches show that a number of hormones in ceratin tumors are growing up. Often, the majority of these hormones are produced by tumor cells or by an unknown origin in the neoplastic area. Also, it is clear that some of these ectopic hormones are produced only by specific tumors. In addition, different effects of these abnormally produced hormones on the immune system ar...
متن کاملسطح بالای پاسخ ایمنی اختصاصی لنفوسیت‌های CD4+وCD8+ نسبت به سیتومگالوویروس و همبستگی بین آن‌ها در بیماران مبتلا به لوسمی لنفوسیتی مزمن سلولB
High level of CMV-specific CD4+ and CD8+cells Immune Response and Correlation Between them in B-cell Chronic Lymphocytic Leukemia Patients B. Pourgheysri [1] , P. Moss [2] Received: 10/09/07 Sent for Revision: 05/03/08 Received Revised Manuscript: 06/12/08 Accepted: 30/12/08 Background and Objective: Chronic lymphocytic leukemia (CLL) is characterized by a monoclonal proliferation o...
متن کاملCD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized with poor effector functions and the expression of multiple inhibitory receptors. Objective: To inve...
متن کاملAnalysis of HLA-G Gene Expression in B-Lymphocytes from Chronic Lymphocytic Leukemia Patients
The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...
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